Inflammatory myofibroblastic tumour of an unusual presentation in

Background Inflammatory myofibroblastic tumour is an infrequent mesenchymal neoplasia of unknown aetiology and variable behaviour, ranging from rather benign lesions to locally aggressive and even metastatic disease. Its presence has been described in almost all organs; however, its location in the female genital tract has rarely been reported. Case presentation We present the case of a 47-year-old female, who was studied in our institution for a recent medical history of several weeks of dyspareunia and abdominal pain. She underwent pertinent studies including ultrasonography and CT scan. Under suspicion of degenerated leiomyoma, a total hysterectomy was performed. Unexpectedly, the pathological study of the surgical specimen showed very few tumour cells with focal fusiform morphology surrounded by an abundant inflammatory infiltrate; a thorough immunohistochemistry study lead to myofibroblastic tumour of the cervix diagnosis. A PET-CT scan did not show metastatic disease. The patient did not undergo any adjuvant treatment, and she is currently on surveillance with no evidence of disease relapse. Conclusions Inflammatory myofibroblastic tumour remains a rare entity yet to be fully elucidated. The diagnosis is based on pathological study due to the lack of typical clinical manifestations and typical radiological images. Surgical resection is the most frequent treatment, whereas chemotherapy and radiotherapy are restricted to locally advanced or metastatic disease. Tirosine kinase inhibitor crizotinib has shown promising results especially in tumours harbouring ALK mutation.

Epithelioid inflammatory myofibroblastic sarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic analysis of five additional cases and review of the literature – topic of research paper in Clinical medicine. Download scholarly

Alfonso López de Sá's research works

Frontiers Inflammatory Myofibroblastic Tumors in the Uterus: Childhood-Case Report and Review of the Literature

PDF) Lower abdominal inflammatory myofibroblastic tumor -an unusual presentation- a case report and brief literature review

Inflammatory myofibroblastic tumor after breast prosthesis: A case report and literature review

Immunohistochemical Features of IMTs

43543 PDFs Review articles in LEIOMYOMA

Rare inflammatory myofibroblastic tumor of the urinary bladder - ScienceDirect

An unusual presentation of a rare soft tissue tumor in the tongue: Inflammatory myofibroblastic tumor - ScienceDirect

In patient 1 the IMT was somewhat ill-defined compared with the